Publications
2025
Rinaldi F., Balboni B., Girotto S., Cavalli A.
An integrative structural study of RAD52, an emerging target in anticancer drug discovery
XXIX National Meeting on Medicinal Chemistry of the Italian Chemistry Society
Poster
Conference
2025
Milordini G., Zacco E., Armaos A., Di Palma F., Masi M., Gilodi M., Rupert J., Broglia L., Varignani G., Oneto M., Scotto M., Marotta R., Girotto S., Cavalli A., Tartaglia G.G.
Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment
bioRxiv
2025
Rinaldi F., Balboni B., Marotta R., Girotto S., Cavalli A.
Elucidating RAD52 architecture through an integrated structural biology approach
51st Meeting of the Italian Crystallographic Association
Poster
Conference
2025
Bresciani V., Rinaldi F., Franco P., Girotto S., Cavalli A., Langer J. D., Masetti M., Bernetti M.
Integrating computational and experimental biophysics reveals novel insights into the RAD51-BRC4 interaction
BiorXiv
2025
Masi M., Poppi L., Previtali V., Nelson S.R., Wynne K., Varignani G., Falchi F., Veronesi M., Albanesi E., Tedesco D., De Franco F., Ciamarone A., Myers S.H., Ortega J.A., Bagnolini G., Ferrandi G., Farabegoli F., Tirelli N., Di Stefano G., Oliviero G., Walsh N., Roberti M., Girotto S., Cavalli A.
Investigating synthetic lethality and PARP inhibitor resistance in pancreatic cancer through enantiomer differential activity
Cell Death Discovery, vol. 11, (no. 1)
2025
Rinaldi F., Bresciani V., Franco P., Veronesi M., Bernetti M., Masetti M., Langer J., Cavalli A., Girotto S.
Probing the BRC repeats RAD51 interaction by integrating computational and experimental biophysics
The 49th FEBS Congress
Poster
Conference
2025
Rinaldi F., Bernetti M., Bresciani V., Veronesi M., Masetti M., Girotto S., Cavalli A.
The mechanistic understanding of the BRCA2-RAD51 interaction: an integrated structural biophysics study
Mammalian DNA Repair Gordon Research Conference: DNA Repair: Fundamental Mechanisms and Human Biology
Poster
Conference
2024
Bagnolini G., Poppi L., Previtali V., Ferrandi G., Rinaldi F., Girotto S., Hirsch A.K.H., Roberti M., Cavalli A.
A journey through targeting BRCA2-RAD51 protein-protein interaction to establish synthetic lethality as paradigm for anticancer drug discovery
National Congress of the Italian Chemistry Society 2024
Poster
Conference
2024
Rinaldi F., Bernetti M., Bresciani V., Girotto S., Cavalli A.
An integrated structural approach reveals novel insights on the BRCA2 - RAD51 interaction
EMBO Practical Course on Small Angle Neutron and X-ray Scattering from biomacromolecules in solution
Poster
Conference
2024
Balboni B., Marotta R., Rinaldi F., Milordini G., Varignani G., Girotto S., Cavalli A.
An integrative structural study of the human full-length RAD52 at 2.2 Å resolution
Communications Biology, vol. 7, (no. 1)
2024
Quaia R., Veronesi M., Anselmi M., Russo D., Penna I., Scarpelli R., Girotto S., Duca M., Bertozzi F., Bandiera T.
Developmental of fluorinated fragments into novel modulators of micro-RNA-21 levels
RNA Technologies Flagship, 2nd Annual Retreat, Genova
Poster
Conference
2024
Brindani N., Vuong L.M., La Serra M.A., Salvador N., Menichetti A., Acquistapace I.M., Ortega J.A., Veronesi M., Bertozzi S.M., Summa M., Girotto S., Bertorelli R., Armirotti A., Ganesan A.K., De Vivo M.
Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy
Journal of Medicinal Chemistry, vol. 67, (no. 12), pp. 10401-10424
2024
Anselmi M., Russo D., Penna I., Quaia R., Bellina F., Panosetti M., Scarpelli R., Veronesi M., Girotto S., Bertozzi F., Duca M., and Bandiera T.
DRUG DISCOVERY PLATFORM FOR THE IDENTIFICATION OF microRNA-21 SMALL-MOLECULE MODULATORS IN PANCREATIC CELLS
RNA Technologies Flagship, 2nd Annual Retreat, Genova
Poster
Conference
2024
Balboni B., Marotta R., Rinaldi F., Milordini G., Varignani G., Girotto S., Cavalli A.
Human full-length RAD52 at 2.2 Å resolution: an integrative structural biology study
Communications Biology
Article
Journal
2024
Romeo E., Saccoliti F., Andonaia A., Allegretta C., Laselva O., Falchi F., Occello R., Liessi N., Armirotti A., Girotto S., Pastorino C., Pedemonte N., Bandiera T., Bertozzi F.
Mechanism of action and binding site characterization of corrector ARN23765 via Photo-Affinity Labeling (PAL) approach in live cells
19th ECFS Basic Science Conference
Poster
Conference